Protein Structural Biology Online Course
This webpage includes freely downloadable videos and presentations based on the book:
Please acknowledge the book when using the materials .
TABLE OF CONTENTS
Chapter 1
Introduction
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What are macromolecules?
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Proteins' biological roles
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The structural base of protein function
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Non-covalent interactions
Chapter 2
Protein structure
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Amino acids properties
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The peptide bond
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Secondary structures
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Tertiary structure of globular proteins
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Structural evolution
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Quaternary structure
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Post-translational modifications
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Fibrous proteins
Chapter 4
Energetics & Stability
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Proteins are marginally stable
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Thermodynamics of protein structure stability
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Physical forces and effects that stabilize or destabilize the folded structure
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Protein denaturation and adaptation to extreme environments
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Protein engineering for increased stability
Chapter 7
Membrane Proteins
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Biological roles
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The lipid bilayer environment
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Integral membrane proteins: structure, composition & energetics
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Peripheral membrane proteins
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Effects of membrane properties and lipids on bound proteins
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G protein-coupled receptors: structure-function relationships
Chapter 5
Dynamics
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The importance of protein dynamics
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Types of motions in proteins and their biological roles
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Theoretical models of protein dynamics
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Thermodynamic and kinetic effects
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External effects on protein dynamics (e.g. ligand binding)
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Protein folding and misfolding
Chapter 8
Protein-Ligand Interactions
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Biological importance
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Binding affinity: measurements, calculations, and thermodynamics
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Binding specificity: models, interactions, binding promiscuity
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Case study: cholinesterase inhibition by toxins and drugs
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Protein-ligand interactions in drug design
Tel-Aviv University course version (videos by lesson)
Chapter 3
Structure Prediction
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Why predict protein structure?
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General apporaches for structure prediction
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The physical approach: explicit and mean-field models
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The comparative approach: homology modeling and fold recognition
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Integrative methods
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Experimentally guided prediction
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Prediction based on co-evolution
Chapter 6
Disordered Proteins
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Prevalence & degrees of disorder
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Biological roles
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Methods for studying these proteins
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Specific functions and mechanisms
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Example: the nuclear pore complex
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Structure-function relationships
Note:
Chapter 9 is in preparation and will be added later on
Last updated: Jun 4 2021